Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming
Identifieur interne : 003598 ( Main/Exploration ); précédent : 003597; suivant : 003599Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming
Auteurs : Martin Picard ; Jiangwen Zhang [République populaire de Chine] ; Saege Hancock ; Olga Derbeneva ; Ryan Golhar ; Pawel Golik [Pologne] ; Sean O Earn ; Shawn Levy ; Prasanth Potluri ; Maria Lvova ; Antonio Davila ; Chun Shi Lin ; Juan Carlos Perin ; Eric F. Rappaport ; Hakon Hakonarson ; Ian A. Trounce [Australie] ; Vincent Procaccio [France] ; Douglas C. WallaceSource :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2014.
Descripteurs français
- KwdFr :
- ADN mitochondrial (génétique), ADN mitochondrial (métabolisme), ARN de transfert de la leucine (génétique), ARN de transfert de la leucine (métabolisme), ARN messager (biosynthèse), ARN messager (génétique), Analyse de séquence d'ARN, Glycolyse (génétique), Humains, Lignée cellulaire tumorale, Maladies génétiques congénitales (anatomopathologie), Maladies génétiques congénitales (génétique), Maladies génétiques congénitales (métabolisme), Mitochondries (génétique), Mitochondries (métabolisme), Mitochondries (ultrastructure), Mutation ponctuelle, Transcription génétique, Transduction du signal (génétique), Épigenèse génétique.
- MESH :
- anatomopathologie : Maladies génétiques congénitales.
- biosynthèse : ARN messager.
- génétique : ADN mitochondrial, ARN de transfert de la leucine, ARN messager, Glycolyse, Maladies génétiques congénitales, Mitochondries, Transduction du signal.
- métabolisme : ADN mitochondrial, ARN de transfert de la leucine, Maladies génétiques congénitales, Mitochondries.
- ultrastructure : Analyse de séquence d'ARN, Humains, Lignée cellulaire tumorale, Mitochondries, Mutation ponctuelle, Transcription génétique, Épigenèse génétique.
English descriptors
- KwdEn :
- Cell Line, Tumor, DNA, Mitochondrial (genetics), DNA, Mitochondrial (metabolism), Epigenesis, Genetic, Genetic Diseases, Inborn (genetics), Genetic Diseases, Inborn (metabolism), Genetic Diseases, Inborn (pathology), Glycolysis (genetics), Humans, Mitochondria (genetics), Mitochondria (metabolism), Mitochondria (ultrastructure), Point Mutation, RNA, Messenger (biosynthesis), RNA, Messenger (genetics), RNA, Transfer, Leu (genetics), RNA, Transfer, Leu (metabolism), Sequence Analysis, RNA, Signal Transduction (genetics), Transcription, Genetic.
- MESH :
- chemical , biosynthesis : RNA, Messenger.
- chemical , genetics : DNA, Mitochondrial, RNA, Messenger, RNA, Transfer, Leu.
- chemical , metabolism : DNA, Mitochondrial, RNA, Transfer, Leu.
- genetics : Genetic Diseases, Inborn, Glycolysis, Mitochondria, Signal Transduction.
- metabolism : Genetic Diseases, Inborn, Mitochondria.
- pathology : Genetic Diseases, Inborn.
- ultrastructure : Mitochondria.
- Cell Line, Tumor, Epigenesis, Genetic, Humans, Point Mutation, Sequence Analysis, RNA, Transcription, Genetic.
Abstract
Mitochondria generate signals that regulate nuclear gene expression via retrograde signaling, but this phenomenon is rendered more complex by the quantitative differences in the percentage of mutant and normal mtDNAs that can exist within patient cells. This study demonstrates that depending upon its relative cytoplasmic levels, a single mtDNA point mutation can cause a discrete set of cellular transcriptional responses within cells of the same nuclear background. This qualitative regulation of nuclear gene expression by quantitative changes in mtDNA mutant levels challenges the traditional “single mutation–single disease” concept and provides an alternative perspective on the molecular basis of complex metabolic and degenerative diseases, cancer, and aging.
Url:
DOI: 10.1073/pnas.1414028111
PubMed: 25192935
PubMed Central: 4183335
Affiliations:
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Le document en format XML
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for Applied Genomics, Division of Genetics, Department of Pediatrics</nlm:aff><wicri:noCountry code="subfield">Department of Pediatrics</wicri:noCountry></affiliation></author><author><name sortKey="Golik, Pawel" sort="Golik, Pawel" uniqKey="Golik P" first="Pawel" last="Golik">Pawel Golik</name><affiliation wicri:level="1"><nlm:aff id="aff6">Institute of Genetics and Biotechnology,<institution>Warsaw University</institution>, 00-927, Warsaw,<country>Poland</country>;</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="O Earn, Sean" sort="O Earn, Sean" uniqKey="O Earn S" first="Sean" last="O Earn">Sean O Earn</name><affiliation><nlm:aff id="aff7">Morton Mower Central Research Laboratory,<institution>Sinai Hospital of Baltimore</institution>, Baltimore,<addr-line>MD</addr-line> 21215;</nlm:aff></affiliation></author><author><name sortKey="Levy, Shawn" sort="Levy, Shawn" uniqKey="Levy S" first="Shawn" last="Levy">Shawn Levy</name><affiliation><nlm:aff id="aff8">Genomics Sevices Laboratory,<institution>HudsonAlpha Institute for Biotechnology</institution>, Huntsville,<addr-line>AL</addr-line> 35806;</nlm:aff></affiliation></author><author><name sortKey="Potluri, Prasanth" sort="Potluri, Prasanth" uniqKey="Potluri P" first="Prasanth" last="Potluri">Prasanth Potluri</name><affiliation><nlm:aff id="aff1">Center for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia and the Department of Pathology and Laboratory Medicine,<institution>University of Pennsylvania</institution>, Philadelphia,<addr-line>PA</addr-line> 19104;</nlm:aff></affiliation></author><author><name sortKey="Lvova, Maria" sort="Lvova, Maria" uniqKey="Lvova M" first="Maria" last="Lvova">Maria Lvova</name><affiliation><nlm:aff id="aff1">Center for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia and the Department of Pathology and Laboratory Medicine,<institution>University of Pennsylvania</institution>, Philadelphia,<addr-line>PA</addr-line> 19104;</nlm:aff></affiliation></author><author><name sortKey="Davila, Antonio" sort="Davila, Antonio" uniqKey="Davila A" first="Antonio" last="Davila">Antonio Davila</name><affiliation><nlm:aff id="aff1">Center for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia and the Department of Pathology and Laboratory Medicine,<institution>University of Pennsylvania</institution>, Philadelphia,<addr-line>PA</addr-line> 19104;</nlm:aff></affiliation></author><author><name sortKey="Lin, Chun Shi" sort="Lin, Chun Shi" uniqKey="Lin C" first="Chun Shi" last="Lin">Chun Shi Lin</name><affiliation><nlm:aff id="aff1">Center for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia and the Department of Pathology and Laboratory Medicine,<institution>University of Pennsylvania</institution>, Philadelphia,<addr-line>PA</addr-line> 19104;</nlm:aff></affiliation></author><author><name sortKey="Perin, Juan Carlos" sort="Perin, Juan Carlos" uniqKey="Perin J" first="Juan Carlos" last="Perin">Juan Carlos Perin</name><affiliation><nlm:aff id="aff5">Nucleic Acid/Protein Research Core Facility,<institution>Children’s Hospital of Philadelphia</institution>, Philadelphia,<addr-line>PA</addr-line> 19104;</nlm:aff></affiliation></author><author><name sortKey="Rappaport, Eric F" sort="Rappaport, Eric F" uniqKey="Rappaport E" first="Eric F." last="Rappaport">Eric F. 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level="a" type="main">Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming</title><author><name sortKey="Picard, Martin" sort="Picard, Martin" uniqKey="Picard M" first="Martin" last="Picard">Martin Picard</name><affiliation><nlm:aff id="aff1">Center for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia and the Department of Pathology and Laboratory Medicine,<institution>University of Pennsylvania</institution>, Philadelphia,<addr-line>PA</addr-line> 19104;</nlm:aff></affiliation></author><author><name sortKey="Zhang, Jiangwen" sort="Zhang, Jiangwen" uniqKey="Zhang J" first="Jiangwen" last="Zhang">Jiangwen Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff2">School of Biological Sciences,<institution>The University of Hong Kong</institution>, Hong Kong,<country>People’s Republic of China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hancock, Saege" sort="Hancock, Saege" uniqKey="Hancock S" first="Saege" last="Hancock">Saege Hancock</name><affiliation><nlm:aff id="aff3"><institution>Trovagene</institution>, San Diego,<addr-line>CA</addr-line> 92130;</nlm:aff></affiliation></author><author><name sortKey="Derbeneva, Olga" sort="Derbeneva, Olga" uniqKey="Derbeneva O" first="Olga" last="Derbeneva">Olga Derbeneva</name><affiliation><nlm:aff id="aff1">Center for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia and the Department of Pathology and Laboratory Medicine,<institution>University of Pennsylvania</institution>, Philadelphia,<addr-line>PA</addr-line> 19104;</nlm:aff></affiliation></author><author><name sortKey="Golhar, Ryan" sort="Golhar, Ryan" uniqKey="Golhar R" first="Ryan" last="Golhar">Ryan Golhar</name><affiliation><nlm:aff wicri:cut=", and" id="aff4">Center for Applied Genomics, Division of Genetics, Department of Pediatrics</nlm:aff><wicri:noCountry code="subfield">Department of Pediatrics</wicri:noCountry></affiliation></author><author><name sortKey="Golik, Pawel" sort="Golik, Pawel" uniqKey="Golik P" first="Pawel" last="Golik">Pawel Golik</name><affiliation wicri:level="1"><nlm:aff id="aff6">Institute of Genetics and Biotechnology,<institution>Warsaw University</institution>, 00-927, Warsaw,<country>Poland</country>;</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="O Earn, Sean" sort="O Earn, Sean" uniqKey="O Earn S" first="Sean" last="O Earn">Sean O Earn</name><affiliation><nlm:aff id="aff7">Morton Mower Central Research Laboratory,<institution>Sinai Hospital of Baltimore</institution>, Baltimore,<addr-line>MD</addr-line> 21215;</nlm:aff></affiliation></author><author><name sortKey="Levy, Shawn" sort="Levy, Shawn" uniqKey="Levy S" first="Shawn" last="Levy">Shawn Levy</name><affiliation><nlm:aff id="aff8">Genomics Sevices Laboratory,<institution>HudsonAlpha Institute for Biotechnology</institution>, Huntsville,<addr-line>AL</addr-line> 35806;</nlm:aff></affiliation></author><author><name sortKey="Potluri, Prasanth" sort="Potluri, Prasanth" uniqKey="Potluri P" first="Prasanth" last="Potluri">Prasanth Potluri</name><affiliation><nlm:aff id="aff1">Center for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia and the Department of Pathology and Laboratory Medicine,<institution>University of Pennsylvania</institution>, Philadelphia,<addr-line>PA</addr-line> 19104;</nlm:aff></affiliation></author><author><name sortKey="Lvova, Maria" sort="Lvova, Maria" uniqKey="Lvova M" first="Maria" last="Lvova">Maria Lvova</name><affiliation><nlm:aff id="aff1">Center for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia and the Department of Pathology and Laboratory Medicine,<institution>University of Pennsylvania</institution>, Philadelphia,<addr-line>PA</addr-line> 19104;</nlm:aff></affiliation></author><author><name sortKey="Davila, Antonio" sort="Davila, Antonio" uniqKey="Davila A" first="Antonio" last="Davila">Antonio Davila</name><affiliation><nlm:aff id="aff1">Center for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia and the Department of Pathology and Laboratory Medicine,<institution>University of Pennsylvania</institution>, Philadelphia,<addr-line>PA</addr-line> 19104;</nlm:aff></affiliation></author><author><name sortKey="Lin, Chun Shi" sort="Lin, Chun Shi" uniqKey="Lin C" first="Chun Shi" last="Lin">Chun Shi Lin</name><affiliation><nlm:aff id="aff1">Center for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia and the Department of Pathology and Laboratory Medicine,<institution>University of Pennsylvania</institution>, Philadelphia,<addr-line>PA</addr-line> 19104;</nlm:aff></affiliation></author><author><name sortKey="Perin, Juan Carlos" sort="Perin, Juan Carlos" uniqKey="Perin J" first="Juan Carlos" last="Perin">Juan Carlos Perin</name><affiliation><nlm:aff id="aff5">Nucleic Acid/Protein Research Core Facility,<institution>Children’s Hospital of Philadelphia</institution>, Philadelphia,<addr-line>PA</addr-line> 19104;</nlm:aff></affiliation></author><author><name sortKey="Rappaport, Eric F" sort="Rappaport, Eric F" uniqKey="Rappaport E" first="Eric F." last="Rappaport">Eric F. Rappaport</name><affiliation><nlm:aff id="aff5">Nucleic Acid/Protein Research Core Facility,<institution>Children’s Hospital of Philadelphia</institution>, Philadelphia,<addr-line>PA</addr-line> 19104;</nlm:aff></affiliation></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><affiliation><nlm:aff id="aff3"><institution>Trovagene</institution>, San Diego,<addr-line>CA</addr-line> 92130;</nlm:aff></affiliation></author><author><name sortKey="Trounce, Ian A" sort="Trounce, Ian A" uniqKey="Trounce I" first="Ian A." last="Trounce">Ian A. Trounce</name><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff9">Centre for Eye Research Australia,<institution>Royal Victorian Eye and Ear Hospital</institution>, East Melbourne, VIC 3002,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Procaccio, Vincent" sort="Procaccio, Vincent" uniqKey="Procaccio V" first="Vincent" last="Procaccio">Vincent Procaccio</name><affiliation wicri:level="1"><nlm:aff id="aff10">Department of Biochemistry and Genetics, National Center for Neurodegenerative and Mitochondrial Diseases,<institution>Centre Hospitalier Universitaire d'Angers</institution>, 49933 Angers,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wallace, Douglas C" sort="Wallace, Douglas C" uniqKey="Wallace D" first="Douglas C." last="Wallace">Douglas C. Wallace</name><affiliation><nlm:aff id="aff1">Center for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia and the Department of Pathology and Laboratory Medicine,<institution>University of Pennsylvania</institution>, Philadelphia,<addr-line>PA</addr-line> 19104;</nlm:aff></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell Line, Tumor</term><term>DNA, Mitochondrial (genetics)</term><term>DNA, Mitochondrial (metabolism)</term><term>Epigenesis, Genetic</term><term>Genetic Diseases, Inborn (genetics)</term><term>Genetic Diseases, Inborn (metabolism)</term><term>Genetic Diseases, Inborn (pathology)</term><term>Glycolysis (genetics)</term><term>Humans</term><term>Mitochondria (genetics)</term><term>Mitochondria (metabolism)</term><term>Mitochondria (ultrastructure)</term><term>Point Mutation</term><term>RNA, Messenger (biosynthesis)</term><term>RNA, Messenger (genetics)</term><term>RNA, Transfer, Leu (genetics)</term><term>RNA, Transfer, Leu (metabolism)</term><term>Sequence Analysis, RNA</term><term>Signal Transduction (genetics)</term><term>Transcription, Genetic</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN mitochondrial (génétique)</term><term>ADN mitochondrial (métabolisme)</term><term>ARN de transfert de la leucine (génétique)</term><term>ARN de transfert de la leucine (métabolisme)</term><term>ARN messager (biosynthèse)</term><term>ARN messager (génétique)</term><term>Analyse de séquence d'ARN</term><term>Glycolyse (génétique)</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Maladies génétiques congénitales (anatomopathologie)</term><term>Maladies génétiques congénitales (génétique)</term><term>Maladies génétiques congénitales (métabolisme)</term><term>Mitochondries (génétique)</term><term>Mitochondries (métabolisme)</term><term>Mitochondries (ultrastructure)</term><term>Mutation ponctuelle</term><term>Transcription génétique</term><term>Transduction du signal (génétique)</term><term>Épigenèse génétique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>RNA, Messenger</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA, Mitochondrial</term><term>RNA, Messenger</term><term>RNA, Transfer, Leu</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>DNA, Mitochondrial</term><term>RNA, Transfer, Leu</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Maladies génétiques congénitales</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>ARN messager</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genetic Diseases, Inborn</term><term>Glycolysis</term><term>Mitochondria</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ADN mitochondrial</term><term>ARN de transfert de la leucine</term><term>ARN messager</term><term>Glycolyse</term><term>Maladies génétiques congénitales</term><term>Mitochondries</term><term>Transduction du signal</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Genetic Diseases, Inborn</term><term>Mitochondria</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ADN mitochondrial</term><term>ARN de transfert de la leucine</term><term>Maladies génétiques congénitales</term><term>Mitochondries</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Genetic Diseases, Inborn</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Mitochondria</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line, Tumor</term><term>Epigenesis, Genetic</term><term>Humans</term><term>Point Mutation</term><term>Sequence Analysis, RNA</term><term>Transcription, Genetic</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="fr"><term>Analyse de séquence d'ARN</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Mitochondries</term><term>Mutation ponctuelle</term><term>Transcription génétique</term><term>Épigenèse génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Significance</title><p>Mitochondria generate signals that regulate nuclear gene expression via retrograde signaling, but this phenomenon is rendered more complex by the quantitative differences in the percentage of mutant and normal mtDNAs that can exist within patient cells. This study demonstrates that depending upon its relative cytoplasmic levels, a single mtDNA point mutation can cause a discrete set of cellular transcriptional responses within cells of the same nuclear background. This qualitative regulation of nuclear gene expression by quantitative changes in mtDNA mutant levels challenges the traditional “single mutation–single disease” concept and provides an alternative perspective on the molecular basis of complex metabolic and degenerative diseases, cancer, and aging.</p></div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Pologne</li><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Davila, Antonio" sort="Davila, Antonio" uniqKey="Davila A" first="Antonio" last="Davila">Antonio Davila</name><name sortKey="Derbeneva, Olga" sort="Derbeneva, Olga" uniqKey="Derbeneva O" first="Olga" last="Derbeneva">Olga Derbeneva</name><name sortKey="Golhar, Ryan" sort="Golhar, Ryan" uniqKey="Golhar R" first="Ryan" last="Golhar">Ryan Golhar</name><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><name sortKey="Hancock, Saege" sort="Hancock, Saege" uniqKey="Hancock S" first="Saege" last="Hancock">Saege Hancock</name><name sortKey="Levy, Shawn" sort="Levy, Shawn" uniqKey="Levy S" first="Shawn" last="Levy">Shawn Levy</name><name sortKey="Lin, Chun Shi" sort="Lin, Chun Shi" uniqKey="Lin C" first="Chun Shi" last="Lin">Chun Shi Lin</name><name sortKey="Lvova, Maria" sort="Lvova, Maria" uniqKey="Lvova M" first="Maria" last="Lvova">Maria Lvova</name><name sortKey="O Earn, Sean" sort="O Earn, Sean" uniqKey="O Earn S" first="Sean" last="O Earn">Sean O Earn</name><name sortKey="Perin, Juan Carlos" sort="Perin, Juan Carlos" uniqKey="Perin J" first="Juan Carlos" last="Perin">Juan Carlos Perin</name><name sortKey="Picard, Martin" sort="Picard, Martin" uniqKey="Picard M" first="Martin" last="Picard">Martin Picard</name><name sortKey="Potluri, Prasanth" sort="Potluri, Prasanth" uniqKey="Potluri P" first="Prasanth" last="Potluri">Prasanth Potluri</name><name sortKey="Rappaport, Eric F" sort="Rappaport, Eric F" uniqKey="Rappaport E" first="Eric F." last="Rappaport">Eric F. Rappaport</name><name sortKey="Wallace, Douglas C" sort="Wallace, Douglas C" uniqKey="Wallace D" first="Douglas C." last="Wallace">Douglas C. Wallace</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Jiangwen" sort="Zhang, Jiangwen" uniqKey="Zhang J" first="Jiangwen" last="Zhang">Jiangwen Zhang</name></noRegion></country><country name="Pologne"><noRegion><name sortKey="Golik, Pawel" sort="Golik, Pawel" uniqKey="Golik P" first="Pawel" last="Golik">Pawel Golik</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Trounce, Ian A" sort="Trounce, Ian A" uniqKey="Trounce I" first="Ian A." last="Trounce">Ian A. Trounce</name></noRegion></country><country name="France"><noRegion><name sortKey="Procaccio, Vincent" sort="Procaccio, Vincent" uniqKey="Procaccio V" first="Vincent" last="Procaccio">Vincent Procaccio</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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